Phosphorus pentachloride → HCID 178479351, 화합물

HRID 616282노트

반응식

HRID 616282 반응식
[ClH:1].[C:2]([NH:10][CH2:11][C:12]([OH:14])=O)(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(Cl)Cl>[ClH:16].[C:2]([NH:10][CH2:11][C:12]([Cl:1])=[O:14])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 178479352HCID 178479352, 화합물

생성물 1

HCID 178479351HCID 178479351, 화합물수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To benzimidoylaminoacetic acid hydrochloride (2.2 g., 10 m moles) in 40 ml. of dry methylene chloride is added 2.5 g. (12 m moles) of phosphorous pentachloride, and the reaction mixture allowed to stir overnight at room temperature. The product is filtered, washed successively with methylene chloride (50 ml.), chloroform 2 × 75 ml.) and hexane (50 ml.) and dried in vacuo, 2.5 g. (99% yield).

후처리

  1. filtrationThe product is filtered
  2. washwashed successively with methylene chloride (50 ml.), chloroform 2 × 75 ml
  3. dry with material) and hexane (50 ml.) and dried in vacuo, 2.5 g

출처 및 근거

ORD 기록
ord-07a05168df484ba5b685aa703703c1f6
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04073783

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