Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 반응물 | 2-Amino-5-methoxybenzamide | HCID 20338217 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide | HCID 59361943 | 133.6% |
반응 단계
To a suspension of 2-amino-5-methoxybenzamide (2.42 g, 14.6 mmol) and pyridine (6 mL) in CHCl3 (120 mL) was added 3-nitrobenzoyl chloride (3.0 g, 16.1 mmol). The resulting mixture was stirred at RT for 6 h. The volatiles were removed in vacuo and the resultant solid was washed with Et2O to give the 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide (6.15 g) which was taken directly on to the next step. HPLC retention time 6.58 mins.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440961B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-fc159f7e15dc4e17a0f43b00764ca618 |
| 출처 메모 | uspto-grants-2016_09 |