Formaldehyde → HCID 20369664, 화합물

HRID 616316노트

반응식

HRID 616316 반응식
[C:1]1([N:7]2[C:11](=[O:12])[NH:10][C:9](=[O:13])[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:14]=[O:15].O>CO.C(Cl)Cl>[C:1]1([N:7]2[C:11](=[O:12])[N:10]([CH2:14][OH:15])[C:9](=[O:13])[O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 962WaterHCID 15620455N-PHENYL-3,5-OXADIAZOLIDIONE

생성물 1

HCID 20369664HCID 20369664, 화합물

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 6344Dichloromethane용매

실험 절차

2-Phenyl-1,2,4-oxadiazolidin-3,5-dione (6.75 grams; 0.044 mole) dissolved in methanol (100 ml) and aqueous formaldehyde (5.67 ml of 37% conc.; 0.06 mole) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux, with stirring for a period of about 2 hours. After this time the reaction mixture was stripped of methanol and water to yield a solid residue. The residue was then dissolved in methylene chloride, and the resulting solution was washed with water. The washed solution was dried over anhydrous magnesium sulfate and stripped of solvent to yield the desired product 2-phenyl-4-hydroxymethyl-1,2,4-oxadiazolidin-3,5-dione as a solid residue.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture was heated
  4. temperatureat reflux
  5. customto yield a solid residue
  6. washthe resulting solution was washed with water
  7. dry with materialThe washed solution was dried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-aac74f6b5a014ee1bd9087154ca51db9
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04073894

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