1,1-Dimethylethyl 5-amino-1H-indazole-1-carboxylate → HCID 59361851, 화합물

HRID 61633노트

반응식

HRID 61633 반응식
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)[N:9]=[C:8]2Cl)(=[O:3])[CH3:2].[NH2:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[N:30]=[CH:29]2>CC(O)C>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=1)[N:9]=[C:8]2[NH:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[N:30]=[CH:29]2)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 198005561,1-Dimethylethyl 5-amino-1H-indazole-1-carboxylateHCID 569494764-Chloro-2-(3-nitrophenyl)quinazolin-6-yl acetate

생성물 1

HCID 59361851HCID 59361851, 화합물수율 92.5%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
95 °C

실험 절차

A mixture of 4-chloro-2-(3-nitrophenyl)quinazolin-6-yl acetate (1.63 g, 4.74 mmol) and tert-butyl 5-amino-1H-indazole-1-carboxylate (1.16 g, 4.28 mmol) in IPA (80 mL) were heated at 95° C. for 5 h. The mixture was allowed to cool to RT, the yellow solid was collected via filtration and washed with Et2O to give the product tert-butyl 5-(6-acetoxy-2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (2.14 g, 3.96 mmol, 84%). HPLC retention time 9.649 min.

후처리

  1. temperatureto cool to RT
  2. filtrationthe yellow solid was collected via filtration
  3. washwashed with Et2O

출처 및 근거

ORD 기록
ord-8e6641f81746459ead4e059ff85bce61
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440961B2

반응 노트

불러오는 중…