2,6-Dihydroxyanthraquinone → 2,6-Bis(2-morpholinoethoxy)anthraquinone dihydrochloride

HRID 616342

반응식

HRID 616342 반응식
[OH:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:17])[CH:10]=3)[C:5](=[O:18])[C:4]=2[CH:3]=1.[ClH:19].[Cl:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.[OH-:29].[K+]>O.C1(C)C=CC=CC=1.ClC1C=CC=CC=1>[ClH:20].[ClH:19].[O:26]1[CH2:27][CH2:28][N:23]([CH2:22][CH2:21][O:1][C:2]2[CH:15]=[CH:14][C:13]3[C:12](=[O:16])[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([O:17][CH2:21][CH2:22][N:23]5[CH2:28][CH2:27][O:29][CH2:25][CH2:24]5)[CH:10]=4)[C:5](=[O:18])[C:4]=3[CH:3]=2)[CH2:24][CH2:25]1

참가 물질

7

반응물 3

HCID 67762,6-DihydroxyanthraquinoneHCID 14797Potassium HydroxideHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

생성물 1

HCID 203697702,6-Bis(2-morpholinoethoxy)anthraquinone dihydrochloride

시약·촉매·용매 3

HCID 962Water용매HCID 1140Toluene용매2회HCID 7964Chlorobenzene용매

실험 절차

This compound was prepared by the method of Example 3, with the exception that toluene was used as the reaction medium rather than chlorobenzene, from 36 g. (0.15 mole) of 2,6-dihydroxyanthraquinone, 100 g. (0.54 mole) of N-(2-chloroethyl) morpholine hydrochloride, 66g. (1.0 mole) of potassium hydroxide pellets (85%), 400 ml. of toluene and 100 ml. of water. The dihydrocholoride salt was recrystallized twice from isopropanol with enough water added to effect solution. The pure compound melted with decomposition at 288-290° C.; λmax (H2 0) 273 μ, E1cm.1% 778.

후처리

  1. customThe dihydrocholoride salt was recrystallized twice from isopropanol with enough water
  2. additionadded
  3. custommelted with decomposition at 288-290° C.

출처 및 근거

ORD 기록
ord-82cee194515f4adb839daa1a4052b408
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04073904

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