Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloroaniline → 5-Chloro-3-(ethylsulfanyl)-3-(2-hydroxyethyl)-1,3-dihydro-2H-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloroaniline | HCID 7812 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 반응물 | 2-Ethylmercaptobutyrolactone | HCID 10877259 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Chloro-3-(ethylsulfanyl)-3-(2-hydroxyethyl)-1,3-dihydro-2H-indol-2-one | HCID 12866418 | — |
반응 단계
To the stirred solution of 5.6 g p-chloroaniline in 150 ml of methylene chloride is added dropwise 4.7 ml of t-butyl hypochlorite in 20 ml of methylene chloride at -65°. After ten minutes, the solution of 5.75 g of 2-ethylmercaptobutyrolactone in 20 ml of methylene chloride is added dropwise and the temperature held at -65° for 2 hours. Then the solution of 6.1 ml of triethylamine in 20 ml of methylene chloride is added dropwise and the mixture is allowed to warm up to room temperature. 50 ml of water are added with stirring and the precipitate filtered off, to yield the 5-chloro-3-(2-hydroxyethyl)-3-ethylmercapto-2-oxindole melting at 132°-135°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04073911 |
| 출처 데이터셋 | uspto-grants-1978_02 |
| ORD ID | ord-b459c9bc0af5466f894841e23c5e3d02 |
| 출처 메모 | uspto-grants-1978_02 |