HCID 20388954, 화합물 → 3-(2-Methyl-1,3-thiazol-5-yl)propan-1-ol
반응식
[CH3:1][C:2]1[S:3][C:4]([CH2:7][CH2:8][C:9](OC)=[O:10])=[CH:5][N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][C:2]1[S:3][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:5][N:6]=1참가 물질
4
실험 절차
10.9 g of methyl 2-methyl-5-thiazole-propanoate in 70 ml of tetrahydrofuran was slowly added with stirring at 10°-15° C to a mixture of 125 ml of tetrahydrofuran and 3.42 g of lithium aluminum hydride at 10° C and the mixture was stirred for about 30 minutes. Then, tetrahydrofuran containing 20% water was slowly added and the mixture was filtered. The filter was washed with ethyl acetate and the filtrate was dried over magnesium sulfate and concentrated under reduced pressure to obtain 8.4 g of raw product which was rectified under reduced pressure to obtain 6.4g of 2-methyl-5-thiazole propanol with a boiling point of 106° C under 0.05 mm Hg.
후처리
- filtrationthe mixture was filtered
- washThe filter was washed with ethyl acetate
- dry with materialthe filtrate was dried over magnesium sulfate
- concentrationconcentrated under reduced pressure
- customto obtain 8.4 g of raw product which
출처 및 근거
- ORD 기록
- ord-f329d76be58645709fdad2cefed6c71b
- 출처 데이터셋
- uspto-grants-1978_02
- 특허 번호
- US04073919
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