Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tert-Butylamine | HCID 6385 | — |
| 반응물 | 3,5-Dibromosalicylaldehyde | HCID 7024 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride | HCID 20308288 | — |
반응 단계
7 gm of 3,5-dibromo-salicylaldehyde, 17.5 gm of tert. butylamine and 7.7 gm of formic acid were heated for 6 hours at 70°-80° C. Subsequently, the reaction mixture was admixed with aqueous 2 N ammonia, vigorously shaken, and the precipitate formed thereby was sucked off. The residue was dissolved in ethanol, acidified with ethanolic hydrochloric acid and admixed with ether in order to crystallize the product out. N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride, m.p. 216°-220° C (decomp.), was obtained after recrystallization from absolute ethanol/ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04073942 |
| 출처 데이터셋 | uspto-grants-1978_02 |
| ORD ID | ord-3136111fc16f4cebb7a7f3363b4d7f1b |
| 출처 메모 | uspto-grants-1978_02 |