Formaldehyde → 2-(Piperidin-1-ylmethyl)prop-2-enenitrile
반응식
[CH2:1]=O.[C:3]([CH2:5][C:6](O)=O)#[N:4].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>O>[N:9]1([CH2:1][C:5](=[CH2:6])[C:3]#[N:4])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1참가 물질
5
실험 절차
Formaldehyde (75 ml of 40% solution) was added to a stirred solution of cyanacetic acid (43g) and piperidine (85g) in water at 15° C. The solution was stirred for 1 hour at room temperature and then boiled under reflux for 2 hours. On cooling the reaction mixture separated into two layers, the top layer was separated and distilled to give a colourless oil, boiling point 117°-118° C 0.5mm.
후처리
- temperatureunder reflux for 2 hours
- temperatureOn cooling the reaction mixture
- customseparated into two layers
- customthe top layer was separated
- distillationdistilled
- customto give a colourless oil, boiling point 117°-118° C 0.5mm
출처 및 근거
- ORD 기록
- ord-d20a6c5b461248b58ca0e08fde2c9bd7
- 출처 데이터셋
- uspto-grants-1978_02
- 특허 번호
- US04074051
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