Dimethylamine → Ethyl 2-dimethylaminomethylacrylate
반응식
[CH2:1]=O.[C:3]([O:9][CH2:10][CH3:11])(=[O:8])[CH2:4][C:5]([O-])=O.[K+].[CH3:13][NH:14][CH3:15]>O>[CH3:13][N:14]([CH2:5][C:4](=[CH2:1])[C:3]([O:9][CH2:10][CH3:11])=[O:8])[CH3:15]참가 물질
5
실험 절차
Formaldehyde (60 ml of 40% solution) was added to a stirred solution of potassium ethyl malonate (34g) and dimethylamine (40 ml of 26% solution) in water (100 ml) at 15° C. The solution was stirred at laboratory temperature for one hour and then boiled under reflux for one hour. After cooling the solution was extracted with ether and the ether was evaporated to leave the product as a yellow oil. This was distilled to give a clear oil (boiling point 84° C/20 mm).
후처리
- temperatureunder reflux for one hour
- temperatureAfter cooling the solution
- extractionwas extracted with ether
- customthe ether was evaporated
출처 및 근거
- ORD 기록
- ord-056f3d710dee46f49a7fd54ed0f847ad
- 출처 데이터셋
- uspto-grants-1978_02
- 특허 번호
- US04074051
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