Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorane, ethylidenetriphenyl- → Ethyl alpha-(3,4-dimethoxyphenyl)crotonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorane, ethylidenetriphenyl- | HCID 137195 | — |
| 반응물 | Benzeneacetic acid, 3,4-dimethoxy-alpha-oxo-, ethyl ester | HCID 170290 | — |
| 촉매 | Phosphonium, ethyltriphenyl-, bromide (1:1) | HCID 73727 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Ethyl alpha-(3,4-dimethoxyphenyl)crotonate | HCID 70615010 | — |
반응 단계
To a diethyl ether solution of ethylidenetriphenylphosphorane prepared in the usual way from 800 g. of ethyltriphenylphosphonium bromide, 400 g. of ethyl 3,4-dimethoxyphenylglyoxylate in 600 ml. of ether are added dropwise. After refluxing for 4-5 hours, the solvent is evaporated and substituted with tetrahydrofuran. The mixture is then heated for 36 hours and then evaporated to dryness and the residue is extracted with diethyl ether in a Soxhlet apparatus giving 150 g. of the title compound. Pursuant to this procedure, the following other α-arylcrotonate starting materials are prepared:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04075241 |
| 출처 데이터셋 | uspto-grants-1978_02 |
| ORD ID | ord-a5755b4f3c46421b8a14187d27c854ba |
| 출처 메모 | uspto-grants-1978_02 |