N-Bromoacetamide → s-Triazolo(5,1-a)isoquinoline, 2-phenyl-

HRID 616697

반응식

HRID 616697 반응식
[C:1]1([C:7]2[N:19]=[C:10]3[C:11]4[C:16]([CH2:17][CH2:18][N:9]3[N:8]=2)=[CH:15][CH:14]=[CH:13][CH:12]=4)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrNC(=O)C>C(Cl)(Cl)(Cl)Cl>[C:1]1([C:7]2[N:19]=[C:10]3[C:11]4[C:16]([CH:17]=[CH:18][N:9]3[N:8]=2)=[CH:15][CH:14]=[CH:13][CH:12]=4)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 4353N-BromoacetamideHCID 134397s-Triazolo(5,1-a)isoquinoline, 5,6-dihydro-2-phenyl-

생성물 1

HCID 169678s-Triazolo(5,1-a)isoquinoline, 2-phenyl-수율 79%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 0.5 g. (0.002 mole) of 2-phenyl-5,6-dihydro-s-triazolo[5,1-a]isoquinoline and 0.28 g. (0.002 mole) of N-bromoacetamide in 10 ml. of carbon tetrachloride is refluxed for 5 hours. The crystalline precipitate which forms is filtered and dissolved in methylene chloride. The resulting solution is washed with sodium bicarbonate, then the solvent is evaporated off and the obtained residue recrystallized from ethyl acetate. Yield 79%.

후처리

  1. additionA mixture of 0.5 g
  2. filtrationThe crystalline precipitate which forms is filtered
  3. dissolutiondissolved in methylene chloride
  4. washThe resulting solution is washed with sodium bicarbonate
  5. customthe solvent is evaporated off
  6. customthe obtained residue recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-4ec79afd853a4edab48144e8f03942db
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075341

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