Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)- → Pyrazolo(5,1-a)isoquinoline, 2-(m-methoxyphenyl)-

HRID 616721노트

반응식

HRID 616721 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[C:12]3[C:13]4[C:18]([CH2:19][CH2:20][N:11]3[N:10]=2)=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH:6]=[CH:7][CH:8]=1>O=[Mn]=O.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:21]=[C:12]3[C:13]4[C:18]([CH:19]=[CH:20][N:11]3[N:10]=2)=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 1

HCID 3045616Pyrazolo(5,1-a)isoquinoline, 5,6-dihydro-2-(3-methoxyphenyl)-

생성물 1

HCID 3045617Pyrazolo(5,1-a)isoquinoline, 2-(m-methoxyphenyl)-

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 241Benzene용매

실험 절차

To a solution of 2.5 g. of 2-(m-methoxyphenyl)-5,6-dihydro-pyrazolo[5,1-a]isoquinoline in 100 ml. of benzene is gradually added with stirring 30 g. of MnO2 prepared as described by E. Pratt et al., J. Org. Chem. 26, 2973 (1961) and activated according to the procedure of J. M. Goldman, J. Org. Chem. 34, 1979 (1969). The obtained mixture is refluxed with stirring for five days, then filtered. The filtrate after evaporation and crystallization of the solid residue from isopropyl ether gives 1 g. of the title product, m.p. 109°-11° C.

후처리

  1. temperatureThe obtained mixture is refluxed
  2. stirringwith stirring for five days
  3. filtrationfiltered
  4. customThe filtrate after evaporation and crystallization of the solid residue from isopropyl ether
  5. customgives 1 g

출처 및 근거

ORD 기록
ord-d765ab1f51f54d80a2975aae4695cbcd
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075342

반응 노트

불러오는 중…