Nitric Acid → 2,5-Dichloro-4-nitrothiophene-3-sulfonyl chloride

HRID 616728노트

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HRID 616728 반응식
[Cl:1][C:2]1[S:3][C:4]([Cl:11])=[CH:5][C:6]=1[S:7]([Cl:10])(=[O:9])=[O:8].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[Cl:1][C:2]1[S:3][C:4]([Cl:11])=[C:5]([N+:12]([O-:14])=[O:13])[C:6]=1[S:7]([Cl:10])(=[O:8])=[O:9]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 27360942,5-Dichlorothiophene-3-sulfonyl chloride

생성물 1

HCID 27772072,5-Dichloro-4-nitrothiophene-3-sulfonyl chloride

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

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온도
25 °C

실험 절차

A 55.8-g (0.22 mol) sample of 2,5-dichloro-3-thienylsulfonyl chloride was added in small portions to a stirred solution of 150 ml concentrated nitric acid and 150 ml concentrated sulfuric acid. After the addition was completed, the reaction mixture was stirred at about 25° C overnight. The reaction mixture was then diluted with ice water and filtered to give the crude 2,5-dichloro-4-nitro-3-thienylsulfonyl chloride product. The product was washed with water and dried. Recrystallization from methylene chloride gave the product as a brown solid, m.p. 89°-91° C.

후처리

  1. additionAfter the addition
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-3c9914eb94ea45afb007253548cff7b7
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075347

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