Amphetamine → HCID 70628179, 화합물

HRID 616764노트

반응식

HRID 616764 반응식
C[CH:2](Cl)[C:3]([NH:5][C:6]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9])=[O:4].[CH3:22][CH:23]([NH2:31])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.O1CCOC[CH2:33]1>C(OCC)C>[ClH:20].[C:25]1([CH2:24][CH:23]([CH3:22])[NH:31][CH2:2][C:3]([N:5]([C:6]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:7]=2[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[CH3:33])=[O:4])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

5

반응물 3

HCID 3007AmphetamineHCID 312751,4-DioxaneHCID 54271004HCID 54271004, 화합물

생성물 1

HCID 70628179HCID 70628179, 화합물수율 58%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

8 g of 2-(methyl-chloroacetamido)-5-chlorobenzophenone and 6.8 g of DL-amphetamine (= DL 1-phenyl-2-aminopropane) in 150 ml of anhydrous dioxan are heated to reflux for 4 hours whilst stirring. The turbid solution is filtered after cooling and evaporated in vacuo and the oily residue is triturated with three times 100 ml of water and dried in vacuo. The oily crude base (8.3 g) thus obtained is dissolved in 400 ml of anhydrous diethyl ether and filtered. 6.5 g of DL-2-(5-phenyl-N-methyl-4-methyl-3-aza-pentanamido)-5-chlorobenzophenone hydrochloride (58% of theory), with a melting point of 132°-135°, are obtained by passing in dry hydrogen chloride gas.

후처리

  1. temperatureto reflux for 4 hours
  2. filtrationThe turbid solution is filtered
  3. temperatureafter cooling
  4. customevaporated in vacuo
  5. customthe oily residue is triturated with three times 100 ml of water
  6. customdried in vacuo
  7. customThe oily crude base (8.3 g) thus obtained
  8. filtrationfiltered

출처 및 근거

ORD 기록
ord-d910216ed45646408a56561299c63c58
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04075409

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