Thiazolidinedione → 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione

HRID 6169

반응식

HRID 6169 반응식
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.N1CCCCC1>C(O)C>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[C:5]2[S:1][C:2](=[O:7])[NH:3][C:4]2=[O:6])=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 5437ThiazolidinedioneHCID 77264-ChlorobenzaldehydeHCID 8082Piperidine

생성물 1

HCID 2330705-(4-Chlorobenzylidene)-2,4-thiazolidinedione수율 43.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of 4-chlorobenzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 17.75 g of the desired compound (43.4% yield, pale yellow crystals).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitated crystals were filtered
  5. washwashed with cooled ethanol

출처 및 근거

ORD 기록
ord-f955cb05073547f09e8e193f4ca25145
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246948

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