p-Toluenesulfonic acid → HCID 20367252, 화합물

HRID 617047노트

반응식

HRID 617047 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][NH:6][NH2:7].C([O:16][C:17](=O)[CH:18]=[C:19]([NH2:23])OCC)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[NH2:23][C:19]1[NH:7][N:6]([CH2:5][C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[C:2]([F:12])([F:13])[F:1])[C:17](=[O:16])[CH:18]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 20367279{[2-(Trifluoromethyl)phenyl]methyl}hydrazine

생성물 1

HCID 20367252HCID 20367252, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

46 g of 2-trifluoromethylbenzylhydrazine were added dropwise, under nitrogen, to a solution of 38.2 g of β-amino-β-ethoxyacrylic acid ethyl ester and 2 g of p-toluenesulphonic acid in 250 ml of ethanol. After stirring overnight, the solvent was distilled off in vacuo and the residue was recrystallised from ethanol. The product was the compound identified above. Melting point: 184°, 22 g (34%).

후처리

  1. distillationthe solvent was distilled off in vacuo
  2. customthe residue was recrystallised from ethanol

출처 및 근거

ORD 기록
ord-54c6040bd8984e269cbb7018a7da4f45
출처 데이터셋
uspto-grants-1978_02
특허 번호
US04076943

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