홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1-Hydroxybenzotriazole → 2-Amino-4-[1-(3,4-dihydroxybenzoyl)-4-piperidinyl]-6-(4-methoxyphenylmethyl)pyrimidine

HRID 617187
노트
인쇄 미리보기

반응식

HRID 617187 반응식
[NH2:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH:5]=[C:4]([CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[N:3]=1.C([O:30][C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][C:39]=1[O:40]CC1C=CC=CC=1)[C:34](O)=[O:35])C1C=CC=CC=1.ON1C2C=CC=CC=2N=N1>ClCCl>[NH2:1][C:2]1[N:3]=[C:4]([CH:17]2[CH2:22][CH2:21][N:20]([C:34](=[O:35])[C:33]3[CH:37]=[CH:38][C:39]([OH:40])=[C:31]([OH:30])[CH:32]=3)[CH2:19][CH2:18]2)[CH:5]=[C:6]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][CH:14]=2)[N:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 757711-HydroxybenzotriazoleHCID 108541553,4-Bis(benzyloxy)benzoic acidHCID 218515322-Amino-4-(4-methoxyphenylmethyl)-6-(4-piperidinyl)pyrimidine

생성물 1

HCID 218515152-Amino-4-[1-(3,4-dihydroxybenzoyl)-4-piperidinyl]-6-(4-methoxyphenylmethyl)pyrimidine수율 203.3%

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

실험 절차

To a solution of 2-amino-4-(4-methoxyphenylmethyl)-6-(4-piperidinyl)pyrimidine (160 mg, 0.54 mmol), 3,4-dibenzyloxybenzoic acid (179 mg, 0.54 mmol) and 1-hydroxybenzotriazole (72 mg, 0.54 mmol) in dichioromethane (150 ml) were added 1-ethyl-3-(N, N'-dimethylaminopropyl)carbodiimide hydrochloride (103 mg, 0.54 mmol) at room temperature under nitrogen atmosphere. After stirring for about 30 minutes, the mixture was washed successively with saturated sodium hydrogen carbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate and then evaporated. The residue was purified by column chromatography (chloroform:methanol=99:1) to give the titled compound (477 mg).

후처리

  1. washthe mixture was washed successively with saturated sodium hydrogen carbonate solution and brine
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. customevaporated
  4. customThe residue was purified by column chromatography (chloroform:methanol=99:1)

출처 및 근거

ORD 기록
ord-e62d668a608c4f56a3b66dc3b0649675
출처 데이터셋
uspto-grants-1999_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05948786

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트