참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 7-Ethyl-5-nitro-1,3-benzothiazole | HCID 22728036 | — |
| 생성물 | 7-Ethyl-5-aminobenzothiazole | HCID 22728029 | 98.4% |
반응 단계
To a solution of SnCl2 (1.5 g, 1.9 mmol) and 5.0 mL of HCl was added 7-ethyl-5-nitrobenzothiazole (0.12 g, 0.57 mmol) in a portion and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aqueous NaOH and extracted with EtOAc and CHCl3. Combined organic layers were dried over Na2SO4 and concentrated in vacuo, yielding an oil (0.10 g, >95%) which was identified as the desired amine (>95% pure) and subjected to a following reaction without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05948804 |
|---|
| 출처 데이터셋 | uspto-grants-1999_09 |
|---|
| ORD ID | ord-499d123d35d843c99eb7d07a04187be9 |
|---|
| 출처 메모 | uspto-grants-1999_09 |
|---|
