Pyridine → 5-chloro-3-((1-methyl-2-(R)-pyrrolidinyl)methoxy)pyridine
반응식
N1C=CC=CC=1.[Cl:7][C:8]1[CH:9]=[C:10]([O:14][CH2:15][C@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[C:21](OC(C)(C)C)=O)[CH:11]=[N:12][CH:13]=1.ClC1C=C(OC[C@@H]2CCCN2C)C=NC=1>CO.C(Cl)(Cl)Cl>[Cl:7][C:8]1[CH:9]=[C:10]([O:14][CH2:15][C@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:11]=[N:12][CH:13]=1참가 물질
5
실험 절차
Following the procedure of Example 16a, replacing the 5-chloro-3-(N-t-butoxycarbonyl-2-S)-pyrrolidinylmethoxy)pyridine thereof with 5-chloro-3-(N-t-butoxycarbonyl-2-(R)-pyrrolidinylmethoxy)pyridine (prepared from the (R)-isomer of the starting material following the procedure of Example 15a), the tide compound was prepared. TLC Rf =0.23 (10% MeOH/CHCl3). MS and 1H NMR (CDCl3, 300 MHz) are similar to 16a.
후처리
- customwas prepared
출처 및 근거
- ORD 기록
- ord-1af3f47d8cce4af389c7692eae79faaf
- 출처 데이터셋
- uspto-grants-1999_09
- 특허 번호
- US05948793
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