Dimethylformamide → 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide
반응식
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13](Br)[CH:14]=1.[C-]#N.[Na+].CN([CH:23]=[O:24])C>O>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13]([O:24][CH3:23])[CH:14]=1참가 물질
5
실험 절차
A sample of 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5bromo-pyridine-N-oxide, from Example 98a above, is reacted with sodium cyanide in DMF and water according to standard procedures. The solvents are removed, and the product is extracted, then purified by chromatography on silica gel.
후처리
- customThe solvents are removed
- extractionthe product is extracted
- custompurified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-89998bd42b784f44b6e4bbf02bf3ce1e
- 출처 데이터셋
- uspto-grants-1999_09
- 특허 번호
- US05948793
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