Hexamethylenediamine → N-(6-Aminohexyl)-4-azidobenzamide

HRID 617682노트

반응식

HRID 617682 반응식
C1C(=O)N(O[C:9]([C:11]2[CH:16]=[CH:15][C:14]([N:17]=[N+:18]=[N-:19])=[CH:13][CH:12]=2)=[O:10])C(=O)C1.[NH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27]>C1COCC1>[N:17]([C:14]1[CH:13]=[CH:12][C:11]([C:9]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])=[O:10])=[CH:16][CH:15]=1)=[N+:18]=[N-:19]

참가 물질

4

반응물 2

HCID 16402HexamethylenediamineHCID 122153Hydroxysuccinimidyl-4-azidobenzoate

생성물 1

HCID 13330101N-(6-Aminohexyl)-4-azidobenzamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2.6 g (10 mmol) HSAB 1 are dissolved in 70 ml THF and dropwise added to solution of 11.62 g (100 mmol) of hexamethylene diamine in THF under stirring and cooled on ice. Subsequently, the ice bath is removed and the temperature is allowed to adjust to room temperature. The solvent is drawn off on the rotation evaporator and excess hexymethylene diamine is removed in a high vacuum as far as possible. The remaining raw product is digested for 20 min in 100 ml of water and subsequently dried overnight in an exsiccator. Product 2b is a slightly yellow to brown solid material.

후처리

  1. temperaturecooled on ice
  2. customSubsequently, the ice bath is removed
  3. customto adjust to room temperature
  4. customThe solvent is drawn off on the rotation evaporator and excess hexymethylene diamine
  5. customis removed in a high vacuum as far as possible

출처 및 근거

ORD 기록
ord-4f0aff6839d54275a7d6139633bbd97f
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952185

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