Water → 2-Benzyloxy-5-(trifluoromethoxy)benzene

HRID 617722노트

반응식

HRID 617722 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:9][C:10]([F:20])([F:19])[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:1]([O:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][C:10]([F:9])([F:19])[F:20])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 70015p-(Trifluoromethoxy)phenol

생성물 1

HCID 215840942-Benzyloxy-5-(trifluoromethoxy)benzene수율 99%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Benzyl bromide (66.17 ml, 95.35 g, 0.56mol) was added to a mixture of 4-(trifluoromethoxy)phenol (90.26 g, 0.51mol) and potassium carbonate (140.97 g, 1.2mol) in dimethylformamide (160 ml) and the mixture was stirred at room temperature for 72 hours. The mixture was poured into water (1.5 l) and extracted with ethyl acetate (3×500 ml). The combined organic fractions were washed with aqueous sodium carbonate (saturated, 500 ml), dried (MgSO4) and the solvent was evaporated under reduced pressure to give the title compound as a colorless solid (133.5 g, 99%). 1H NMR (360 MHz, CDCl3) δ 7.39 (5H, m), 7.14 (2H, d, J=9.0 Hz), 6.95 (2H, d, J=9.0 Hz), and 5.05 (2H, s).

후처리

  1. extractionextracted with ethyl acetate (3×500 ml)
  2. washThe combined organic fractions were washed with aqueous sodium carbonate (saturated, 500 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9e6d89563290408ba29dcac8d21b17a0
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952315

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