Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Diethyl 2-acetamido-2-docosylmalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| 반응물 | 1-Bromodocosane | HCID 81355 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Diethyl 2-acetamido-2-docosylmalonate | HCID 21849362 | 57.8% |
반응 단계
Diethyl 2-acetamidomalonate (3.0 g) was dissolved in 50 ml of dry ethanol and 1.3 g of sodium ethoxide was added thereto. A solution of 6.5 g of docosyl bromide in 20 ml of dry ethanol was added thereto while stirring at room temperature. The inside of the reaction vessel was displaced with nitrogen and the mixture was refluxed for about 15 hours. The mixture was neutralized with a 1 N aqueous hydrochloric acid solution and concentrated. The concentrate was purified by silica gel column chromatography to give 4.2 g of diethyl 2-acetamido-2-docosylmalonate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952316 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-4418efd7bff54d348a7758b0afcb391b |
| 출처 메모 | uspto-grants-1999_09 |