Tert-butyl 4-(1,8-naphthyridin-2-yl)piperidine-1-carboxylate → tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

HRID 617907노트

반응식

HRID 617907 반응식
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>[Pd].CCOC(C)=O>[C:1]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH2:18][NH:17][C:16]=3[N:15]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 22626613Tert-butyl 4-(1,8-naphthyridin-2-yl)piperidine-1-carboxylate

생성물 1

HCID 11197916tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-3 (2.6 g, 8.4 mmol), 10% Pd/C (0.52 g), and EtOAc (100 mL) was stirred under a hydrogen atmosphere (1 atm) for 20 hr. The reaction mixture was then filtered through a celite pad and the filtrate concentrated. Flash chromatography (silica, 70% hexanes/EtOAc to EtOAc) gave 4-4 as a colorless oil.

후처리

  1. filtrationThe reaction mixture was then filtered through a celite pad
  2. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-54bb8e806bbe4aacaaf1421bf975505d
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952341

반응 노트

불러오는 중…