Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 4,6-Diaminonicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 4,6-Diamino-2-bromo-3-pyridinecarbonitrile | HCID 170668 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4,6-Diaminonicotinonitrile | HCID 295896 | — |
반응 단계
A suspension of 21.3 g of 6-bromo-2,4-diamino-5-cyanopyridine (JACS, 80:2838-2840 (1958)) and 1 g of 20% palladium on charcoal in 250 mL of tetrahydrofuran was shaken in a Parr apparatus under an atmosphere hydrogen. After 2 hours, the reaction was stopped and 10 g of potassium acetate and 50 mL of methanol added. The reaction was recharged with hydrogen and shaken for 18 hours. The solvents were removed under reduced pressure and the residue crystallized from isopropyl alcohol to afford the title compound 2,4-diamino-5-cyanopyridine, mp 201-202° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952342 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-c68c356a278b4eea9c94eb125607496a |
| 출처 메모 | uspto-grants-1999_09 |