Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexyl isocyanate → 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexyl isocyanate | HCID 18502 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328133 | — |
| 반응물 | Acetonitrile methanol | HCID 21959252 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea | HCID 5328136 | 71.9% |
반응 단계
6-(2, 6-Dichlorophenyl)-N2 -(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 53 in DMF (15 mL) was reacted with 60% sodium hydride suspension (0.092 g) and cyclohexyl isocyanate (0.289 g) according to the general procedure of Example 54 to give 0.927 g of the title compound, ESMS (20/80 MeOH/CH3CN+0.1% AcOH): M+ +H=558, 433.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952342 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-31a0e7741e3a42f2a6c7b1404d737440 |
| 출처 메모 | uspto-grants-1999_09 |