Ammonium Hydroxide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester
반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([S:13][CH3:14])[N:3]=1.[OH-].[NH4+:16]>C(O)C>[CH2:11]([O:10][C:8]([C:7]1[C:2]([NH2:16])=[N:3][C:4]([S:13][CH3:14])=[N:5][CH:6]=1)=[O:9])[CH3:12]참가 물질
4
실험 절차
To a suspension of ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate (25 g) in ethanol (200 mL) was added 30% ammonium hydroxide (38 mL). After stirring 5 hours at room temperature, the reaction was concentrated in vacuo. The residue was suspended in water and filtered. The filter pad, washed with water then diethyl ether, gave 17.68 g of the title compound, CIMS (1% NH3 in CH4): 242=M+ +C2H5, 214=M+ +H (Base), 213=M+, 168=M+ -OEt.
후처리
- concentrationthe reaction was concentrated in vacuo
- filtrationfiltered
- washThe filter pad, washed with water
출처 및 근거
- ORD 기록
- ord-02618b0e8ba54692afa0e06d45d27c93
- 출처 데이터셋
- uspto-grants-1999_09
- 특허 번호
- US05952342
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