tert-Butyl isocyanate → 1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea

HRID 617966노트

반응식

HRID 617966 반응식
[C:1]1([C:7]2[C:17]([NH2:18])=[N:16][C:10]3[N:11]=[C:12]([NH2:15])[N:13]=[CH:14][C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:19]([N:23]=[C:24]=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[NH2:15][C:12]1[N:13]=[CH:14][C:9]2[CH:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:17]([NH:18][C:24]([NH:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:25])=[N:16][C:10]=2[N:11]=1

참가 물질

3

반응물 2

HCID 62412tert-Butyl isocyanateHCID 108474752,7-Diamino-6-phenylpyrido[2,3-d]pyrimidine

생성물 1

HCID 53291111-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea

실험 절차

Following the procedure of Example 2, 0.246 g of 6-phenyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 81 was reacted with 0.128 mL of tert-butyl isocyanate. The product is purified by medium pressure chromatography using silica gel and eluting with a gradient of 1:1 CHCl3 :EtOAc to EtOAc to afford the title compound; mp >250° C., CIMS (1% ammonia in methane): m/z (relative intensity) 337 (MH+ +1, 64), 338 (MH+ +2, 11), 236 (100).

후처리

  1. customThe product is purified by medium pressure chromatography
  2. washeluting with a gradient of 1:1 CHCl3

출처 및 근거

ORD 기록
ord-6e3a24cd12ef49d6aede7e47e5de1e4e
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952342

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