참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | 7-Methoxy-1,1-dimethyl-3,4-dihydronaphthalen-2(1H)-one | HCID 13011007 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-Chloro-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one | HCID 66834407 | — |
반응 단계
7-Methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one (Compound A2, 3.37 g, 16.5 mmol) was dissolved in CH3CN (82 mL), added with NCS (2.42 g, 1.1 eq.) and stirred at 90° C. for 1.5 hr. The reaction solution was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over sodium sulfate. The drying agent was removed and the target compound was obtained after concentration under reduced pressure (yellow oily substance, 4.45 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440922B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-48af45ea058b4e8ba776631f7e605741 |
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| 출처 메모 | uspto-grants-2016_09 |
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