Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropyl isocyanate → 6-Arylpyrido[2,3-d]pyrimidine deriv. 30
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropyl isocyanate | HCID 61277 | — |
| 반응물 | 6-(2,6-dichlorophenyl)-2-N-[3-(diethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328114 | — |
| 생성물 | 6-Arylpyrido[2,3-d]pyrimidine deriv. 30 | HCID 5328132 | — |
반응 단계
The procedure of Example 21 was followed to react 0.30 g of 7-amino-6-(2,6-dichlorophenyl)-2-(3-diethylamino-propylamino)-pyrido[2,3-d]pyrimidine from Example 20 and 0.077 mL of isopropyl isocyanate. The product was purified by medium pressure chromatography on silica gel eluting with 90:10:1 EtOAc:MeOH:TEA to afford the title compound, mp 88-100° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 504 (MH+, 3), 506 (MH+ +2, 2), 86 (100)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952342 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-00e4f5089a1140d2af2b4f34d7a5060c |
| 출처 메모 | uspto-grants-1999_09 |