Isopropyl isocyanate → 6-Arylpyrido[2,3-d]pyrimidine deriv. 30

HRID 617995

반응식

HRID 617995 반응식
[NH2:1][C:2]1[C:3]([C:21]2[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:28])=[CH:4][C:5]2[CH:10]=[N:9][C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])=[N:7][C:6]=2[N:20]=1.[CH:29]([N:32]=[C:33]=[O:34])([CH3:31])[CH3:30]>>[Cl:28][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([Cl:27])[C:21]=1[C:3]1[C:2]([NH:1][C:33]([NH:32][CH:29]([CH3:31])[CH3:30])=[O:34])=[N:20][C:6]2[N:7]=[C:8]([NH:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[N:9]=[CH:10][C:5]=2[CH:4]=1

참가 물질

3

반응물 2

HCID 61277Isopropyl isocyanateHCID 53281146-(2,6-dichlorophenyl)-2-N-[3-(diethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine

생성물 1

HCID 53281326-Arylpyrido[2,3-d]pyrimidine deriv. 30

실험 절차

The procedure of Example 21 was followed to react 0.30 g of 7-amino-6-(2,6-dichlorophenyl)-2-(3-diethylamino-propylamino)-pyrido[2,3-d]pyrimidine from Example 20 and 0.077 mL of isopropyl isocyanate. The product was purified by medium pressure chromatography on silica gel eluting with 90:10:1 EtOAc:MeOH:TEA to afford the title compound, mp 88-100° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 504 (MH+, 3), 506 (MH+ +2, 2), 86 (100)

후처리

  1. customThe product was purified by medium pressure chromatography on silica gel eluting with 90:10:1 EtOAc

출처 및 근거

ORD 기록
ord-00e4f5089a1140d2af2b4f34d7a5060c
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952342

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