Water → (2,6-Dimethyl-3-nitrophenyl)methanol

HRID 618239

반응식

HRID 618239 반응식
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[C:4](O)=[O:5].B.O>O1CCCC1>[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([CH3:14])[C:3]=1[CH2:4][OH:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 6331BoraneHCID 2393292,6-Dimethyl-3-nitrobenzoic acid

생성물 1

HCID 10487641(2,6-Dimethyl-3-nitrophenyl)methanol수율 93.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
75 °C

실험 절차

2,6-Dimethyl-3-nitrobenzoic acid (10 g) was dissolved in 100 ml of dry tetrahydrofuran and 165 ml of 1M borane in tetrahydrofuran added. The mixture was heated to 75° C. for 4 hr. The mixture was cooled to room temperature and the excess reagent slowly decomposed with water and the solvent evaporated. The residue was treated with ethyl acetate, washed with 1M hydrochloric acid, then with water, dried, and evaporated to give 8.71 g of (2,6-dimethyl-3-nitro-phenyl)-methanol, mp 94.5-96.1° C. ##STR124##

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. customthe solvent evaporated
  3. additionThe residue was treated with ethyl acetate
  4. washwashed with 1M hydrochloric acid
  5. dry with materialwith water, dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-57dc12dc7ae8494196565dd1f0c22521
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952362

연결된 노트

불러오는 중…