N-methanesulfonyl-6-hydroxymethylindole → 5-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene

HRID 618247노트

반응식

HRID 618247 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12]O)[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[CH3:8].CS(N1C2C(=CC=C(C[Br:28])C=2)C=C1)(=O)=O.CS(N1C2C(=CC=C(CO)C=2)C=C1)(=O)=O>>[Br:28][CH2:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]([CH3:8])=[C:2]([Cl:1])[CH:3]=1

참가 물질

4

반응물 3

HCID 18789614N-methanesulfonyl-6-hydroxymethylindoleHCID 18789641N-methanesulfonyl-6-bromomethylindoleHCID 18789738(3-Chloro-4-methyl-5-nitrophenyl)methanol

생성물 1

HCID 187896735-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene

실험 절차

5-Bromomethyl-1-chloro-2-methyl-3-nitrobenzene was prepared from (3-chloro-4-methyl-5-nitrophenyl)methanol in a manner similar to that described in Example 10 for the preparation of N-methanesulfonyl-6-bromomethylindole from N-methanesulfonyl-6-hyroxymethyl indole.

출처 및 근거

ORD 기록
ord-43b921327faf4ed4a52e62a784e02be2
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952362

반응 노트

불러오는 중…