1-methanesulfonyl-3-methyl-6-nitro-1H-indole → 1-methanesulfonyl-3-methyl-6-amino-1H-indole
반응식
[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-])=O)[CH:12]=2)[C:7]([CH3:17])=[CH:6]1)(=[O:4])=[O:3]>C(O)C.[Pt]=O>[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[C:7]([CH3:17])=[CH:6]1)(=[O:4])=[O:3]참가 물질
4
실험 절차
A mixture of 1-methanesulfonyl-3-methyl-6-nitro-1H-indole (1.17 g, 4.60 mmol) and platinum oxide (52 mg, 0.23 mmol) in 20 ml of absolute ethanol was stirred at room temperature under an atmosphere of hydrogen gas for 12 hr. The mixture was filtered through a fine Whatman glass fiber filter to remove the catalyst. A quantitative amount of 1-methanesulfonyl-3-methyl-6-amino-1H-indole was obtained after removing the ethanol at reduced pressure.
후처리
- filtrationThe mixture was filtered through a fine Whatman glass fiber
- filtrationfilter
- customto remove the catalyst
출처 및 근거
- ORD 기록
- ord-92379c8546ed4fa1928c92a7f3c39071
- 출처 데이터셋
- uspto-grants-1999_09
- 특허 번호
- US05952362
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