홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → 4-[[[(6-Hydroxyhexyl)amino]-carbonyl]oxy]-1-piperidinecarboxylic acid 4-phenoxyphenyl ester

HRID 618287
노트
인쇄 미리보기

반응식

HRID 618287 반응식
C(N(CC)CC)C.[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15].[O:16]([C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([N:32]2[CH2:37][CH2:36][CH:35]([O:38][C:39](OC3C=CC([N+]([O-])=O)=CC=3)=[O:40])[CH2:34][CH2:33]2)=[O:31])=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(Cl)Cl>[O:16]([C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([N:32]2[CH2:33][CH2:34][CH:35]([O:38][C:39]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])=[O:40])[CH2:36][CH2:37]2)=[O:31])=[CH:25][CH:24]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 199606-Amino-1-hexanolHCID 54469753HCID 54469753, 화합물

생성물 1

HCID 537895824-[[[(6-Hydroxyhexyl)amino]-carbonyl]oxy]-1-piperidinecarboxylic acid 4-phenoxyphenyl ester수율 114.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of triethylamine (65.5 mL, 0.47 mol) and 6-aminohexanol (13.2 g, 0.11 mol) in 300 mL of methylene chloride was added dropwise under nitrogen to a solution of the carbonate (45.0 g, 0.09 mol) produced in Example 3 in 500 mL of methylene chloride at room temperature. After the addition the solution was stirred at room temperature overnight. The reaction was extracted one time with 1N HCl and then multiple times with saturated Na2CO3, dried (MgSO4) and the solvent removed under reduced pressure to give 47.0 g of an off-white solid. Recrystallization from methylene chloride-diisopropyl ether gave 35.5 g (83%) of the title compound as a white crystalline solid, mp 69-72° C.

후처리

  1. additionAfter the addition the solution
  2. extractionThe reaction was extracted one time with 1N HCl
  3. dry with materialmultiple times with saturated Na2CO3, dried (MgSO4)
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-70cd0b67a5354b49a9e0e56896c3a9d8
출처 데이터셋
uspto-grants-1999_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05952354

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트