Methyl 4-bromobenzoate → Methyl 4-[7-(1-adamantyl)-6-benzyloxy-2-naphthyl]benzoate

HRID 618484

반응식

HRID 618484 반응식
[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17](B(O)O)=[CH:18]4)=[CH:13][C:12]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.Br[C:33]1[CH:42]=[CH:41][C:36]([C:37]([O:39][CH3:40])=[O:38])=[CH:35][CH:34]=1>>[C:1]12([C:11]3[CH:20]=[C:19]4[C:14]([CH:15]=[CH:16][C:17]([C:33]5[CH:42]=[CH:41][C:36]([C:37]([O:39][CH3:40])=[O:38])=[CH:35][CH:34]=5)=[CH:18]4)=[CH:13][C:12]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

3

반응물 2

HCID 12081Methyl 4-bromobenzoateHCID 220003137-(1-Adamantyl)-6-benzyloxy-2-naphthylboronic acid

생성물 1

HCID 22000300Methyl 4-[7-(1-adamantyl)-6-benzyloxy-2-naphthyl]benzoate수율 72.3%

실험 절차

Following the procedure of Example 1(c), but reacting 2.8 g (6.7 mmol) of 7-(1-adamantyl)-6-benzyloxy-2-naphthylboronic acid with 950 mg (4.4 mmol) of methyl 4-bromobenzoate, 1.6 g (72%) of the expected compound were obtained.

출처 및 근거

ORD 기록
ord-341de7cc77f94e5ab1320a6205134ce5
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952382

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