Water → HCID 22000329, 화합물

HRID 618503

반응식

HRID 618503 반응식
[C:1]([O:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(N([CH2:17][CH3:18])CC)C.[C:19]12([C:29]3[CH:38]=[C:37]4[C:32]([CH:33]=[CH:34][C:35]([C:41]5[CH:49]=[CH:48][C:44]([C:45](Cl)=[O:46])=[CH:43][CH:42]=5)=[C:36]4[O:39][CH3:40])=[CH:31][C:30]=3[O:50][CH2:51]COC)[CH2:28][CH:23]3[CH2:24][CH:25]([CH2:27][CH:21]([CH2:22]3)[CH2:20]1)[CH2:26]2.[OH2:55]>C1COCC1>[C:1]([O:4][C:5]1[CH:11]=[CH:10][C:8]([NH:9][C:45](=[O:46])[C:44]2[CH:48]=[CH:49][C:41]([C:35]3[CH:34]=[CH:33][C:32]4[C:37](=[CH:38][C:29]([C:19]56[CH2:26][CH:25]7[CH2:24][CH:23]([CH2:22][CH:21]([CH2:27]7)[CH2:20]5)[CH2:28]6)=[C:30]([O:50][CH3:51])[CH:31]=4)[C:36]=3[O:39][CH2:40][O:55][CH2:17][CH3:18])=[CH:42][CH:43]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 83783Phenol, 4-amino-, 1-acetateHCID 131721374HCID 131721374, 화합물

생성물 1

HCID 22000329HCID 22000329, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

970 mg (6.4 mmol) of 4-acetoxyaniline, 50 ml of THF and 990 μl (7 mmol) of triethylamine were introduced into a round-bottomed flask. A solution of 3.2 g (6.4 mmol) of 4-[7-(1-adamantyl)-6-methoxyethoxy-methoxy-2-naphthyl]benzoic acid chloride in THF was added dropwise and the reaction mixture was stirred at room temperature for two hours. The reaction mixture was poured into water and extracted with ethyl acetate and the organic phase was separated by settling, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane, filtered and dried. 3.15 g (81%) of the expected compound were collected, which compound had a melting point of 206°-7° C.

후처리

  1. extractionextracted with ethyl acetate
  2. customthe organic phase was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe residue obtained
  6. customwas triturated in heptane
  7. filtrationfiltered
  8. customdried
  9. custom3.15 g (81%) of the expected compound were collected

출처 및 근거

ORD 기록
ord-4ab03eda088a46eab3e2f958a65f9208
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05952382

연결된 노트

불러오는 중…