Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Dihydroartemisinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | Artemisinic Acid | HCID 10922465 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Dihydroartemisinic acid | HCID 11020893 | — |
반응 단계
A process as claimed in step (x) of claim 1, wherein reduction in step (x) comprises (i) dissolving artemisinic acid and NiCl2.6H2O in dry methanol; (ii) adding sodium borohydride to the resultant solution at 0° C. over a 2 hr. period; (iii) neutralising the solution obtained in step (ii) with 5% aqueous HCl solution and (iv) isolating and crystallizing the dihydro artemisinic acid in ethyl acetate to obtain pure dihydro artemisinic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05955084 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-afead0b5bfee482e863fbb212dd1b31e |
| 출처 메모 | uspto-grants-1999_09 |