Hydrochloric Acid → Dihydroartemisinic acid

HRID 618608

반응식

HRID 618608 반응식
[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C:13]([C:15]([OH:17])=[O:16])=[CH2:14])[CH2:4][CH2:3]1.[BH4-].[Na+].Cl>CO>[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C@H:13]([C:15]([OH:17])=[O:16])[CH3:14])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10922465Artemisinic Acid

생성물 1

HCID 11020893Dihydroartemisinic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A process as claimed in step (x) of claim 1, wherein reduction in step (x) comprises (i) dissolving artemisinic acid and NiCl2.6H2O in dry methanol; (ii) adding sodium borohydride to the resultant solution at 0° C. over a 2 hr. period; (iii) neutralising the solution obtained in step (ii) with 5% aqueous HCl solution and (iv) isolating and crystallizing the dihydro artemisinic acid in ethyl acetate to obtain pure dihydro artemisinic acid.

후처리

  1. customisolating
  2. customcrystallizing the dihydro artemisinic acid in ethyl acetate

출처 및 근거

ORD 기록
ord-afead0b5bfee482e863fbb212dd1b31e
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955084

연결된 노트

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