2-(1-Benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid → HCID 66835213, 화합물

HRID 61866노트

반응식

HRID 61866 반응식
[S:1]1[C:5]([C:6]([C:9]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=O)([CH3:8])[CH3:7])=[CH:4][C:3]2[CH:20]=[CH:21][CH:22]=[CH:23][C:2]1=2>O>[CH3:19][O:18][C:16]1[CH:17]=[C:9]2[C:10](=[CH:14][CH:15]=1)[C:11](=[O:13])[C:4]1[C:3]3[CH:20]=[CH:21][CH:22]=[CH:23][C:2]=3[S:1][C:5]=1[C:6]2([CH3:7])[CH3:8]

참가 물질

3

반응물 1

HCID 668347002-(1-Benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid

생성물 1

HCID 66835213HCID 66835213, 화합물수율 63%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

To 2-(1-benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid (Compound Z4, 68 mg, 0.22 mmol), polyphosphoric acid (3.5 g) was added, and the mixture was stirred for 1 hr at 100° C. under heating. The mixture was added with water, extracted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (41 mg, 63%).

후처리

  1. temperatureunder heating
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. customThe residues obtained
  6. concentrationafter concentration under reduced pressure
  7. customwere purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-6bbfad9e6b2844568b529556b7db471e
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440922B2

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