Piperidine → Ethyl 4-(2-Piperidinoethoxy)benzoate

HRID 618800

반응식

CS([CH2:5][CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=1)(=O)=O.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C([O-])([O-])=O.[K+].[K+]>>[N:19]1([CH2:5][CH2:6][O:7][C:8]2[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][CH:9]=2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

반응물 3

HCID 8082Piperidine

HCID 11430Potassium Carbonate

HCID 13259457Ethyl 4-[2-(methanesulfonyl)ethoxy]benzoate

생성물 1

HCID 9838504Ethyl 4-(2-Piperidinoethoxy)benzoate

반응 조건

온도: 80 °C

실험 절차

To a 25 mL round bottom flask with magnetic stirring and condenser and under nitrogen were added the following: the solution from step 2 containing about 10.0 mmol of ethyl 4-(2-methanesulfonylethoxy)benzoate, 2 mL (20 mmol) of piperidine, and 1.5 g K2CO3. The mixture was heated to 80° C. for 24 hours and then to 125° C. for an additional 24 hours to yield product. The yield was estimated to exceed 90%. The product was identical by chromatography and 1H-NMR to that found by published methods.

후처리

customto 125° C. for an additional 24 hours to yield product

출처 및 근거

ORD 기록: ord-71ef1559c29d4620875ff4d9ac1f9263
출처 데이터셋: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05955608

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