1-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide → 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

HRID 618804노트

반응식

HRID 618804 반응식
[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH2:13][CH2:14][CH3:15])=[N:3]1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:10][C:5]1[C:4]([CH2:13][CH2:14][CH3:15])=[N:3][N:2]([CH3:1])[C:6]=1[C:7]([NH2:9])=[O:8]

참가 물질

5

반응물 2

HCID 27544921-Methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 33380444-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A stirred suspension of 1-methyl4-nitro-3-n-propylpyrazole-5-carboxamide (EP-A-0463756; 237.7 g, 1.12 mol) and 5% palladium on charcoal (47.5 g) in ethyl acetate (2.02 l) was hydrogenated at 344.7 kPa (50 psi) and 50° C. for 4 hours, when the uptake of hydrogen was complete. The cool reaction mixture was filtered, then the filter pad washed with ethyl acetate, the combined filtrate and washings thus furnishing an ethyl acetate solution of the title compound (EP-A-0463756) which was of sufficient purity to use directly in the next stage of the reaction sequence (see Preparation 4).

후처리

  1. customThe cool reaction mixture
  2. filtrationwas filtered
  3. washthe filter pad washed with ethyl acetate

출처 및 근거

ORD 기록
ord-2c5b9173c24a489b801f00bda7fd8540
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955611

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