Acetone → (E)-6-Methyl-3-hepten-2-one

HRID 618863노트

반응식

HRID 618863 반응식
[CH:1](=O)[CH2:2][CH:3]([CH3:5])[CH3:4].[CH3:7][C:8]([CH3:10])=[O:9]>>[CH3:4][CH:3]([CH3:5])[CH2:2][CH:1]=[CH:7][C:8](=[O:9])[CH3:10]

참가 물질

3

반응물 2

HCID 180AcetoneHCID 115523-Methylbutanal

생성물 1

HCID 137281(E)-6-Methyl-3-hepten-2-one수율 35%

실험 절차

In contrast, the processes comprising subjecting isovaleraldehyde and acetone to aldol condensation in the presence of an aqueous alkali have an advantage that the reaction can be carried out under mild conditions, using inexpensive materials. The process (iv), however, can give 6-methyl-3-hepten-2-one, the aldol condensate, only in a 35 to 40% yield at most. Also, the process (v) mainly forms 6-methyl-4-hydroxyheptan-2-one, and requires successive dehydration reaction in order to obtain the yield of the 6-methyl-3-hepten-2-one. In addition, the yield of the 6-methyl-3-hepten-2-one thus obtained is 51%, which is not satisfactory. Moreover, the process (v) must use acetone in excess, so it is not industrially advantageous in view of the necessity for recovering the excessive acetone and the volumetric efficiency of reaction.

후처리

  1. customcondensation in the presence of an aqueous alkali
  2. customthat the reaction

출처 및 근거

ORD 기록
ord-da3969c245de44d7aa2b1d10ffba6992
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05955636

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