Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromoethanol → N,N'-bis[2,4,6-triiodo-3-(2-hydroxyethylaminocarbonyl)-5-(1,3-dihydroxyprop-2-ylaminocarbonyl)-phenyl]-N-hydroxyethylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromoethanol | HCID 10898 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N,N'-bis[2,4,6-triiodo-3-(2-hydroxyethylaminocarbonyl)-5-(1,3-dihydroxyprop-2-ylaminocarbonyl)-phenyl]urea | HCID 21844888 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N,N'-bis[2,4,6-triiodo-3-(2-hydroxyethylaminocarbonyl)-5-(1,3-dihydroxyprop-2-ylaminocarbonyl)-phenyl]-N-hydroxyethylurea | HCID 86754527 | — |
반응 단계
N,N'-bis[2,4,6-triiodo-3-(2-hydroxyethylaminocarbonyl)-5-(1,3-dihydroxyprop-2-ylaminocarbonyl)-phenyl]urea (0.27 g, 0.2 mmol) from Example 4 was dissolved in water (7 ml) containing 2M aqueous NaOH (1.0 ml) and 2-bromoethanol (0.084 ml, 1.2 mmol). After stirring for 20 h, the solution was neutralized with a strongly acidic cation exchange resin and evaporated to dryness. The residue was purified by preparative HPLC. Yield 138 mg (50%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05958375 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-d7ebc3e8adac4337bf2dc72421807102 |
| 출처 메모 | uspto-grants-1999_09 |