Cyclohexylbenzene → 4-Cyclohexylbenzene-1-sulfonyl chloride

HRID 619074

반응식

HRID 619074 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][S:14](O)(=[O:16])=[O:15].[Cl-].[NH4+]>C(Cl)Cl>[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 13229CyclohexylbenzeneHCID 24638Chlorosulfonic acidHCID 25517Ammonium Chloride

생성물 1

HCID 43394424-Cyclohexylbenzene-1-sulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
5 °C

실험 절차

A solution of 10.6 ml of phenylcyclohexane in 100 ml of methylene chloride was added at 5° C. within 30 minutes to 13.8 ml of chlorosulfonic acid. The mixture was stirred at 5° C. for 1 hour, poured into 400 ml of a 20% ammonium chloride solution and extracted twice with 300 ml of methylene chloride each time. The organic phases were combined, dried with magnesium sulphate and the solvent was removed on a rotary evaporator. 13.6 g of 4-cyclohexyl-benzenesulfonyl chloride separated as a reddish oil, which was used without further purification.

후처리

  1. extractionextracted twice with 300 ml of methylene chloride each time
  2. dry with materialdried with magnesium sulphate
  3. customthe solvent was removed on a rotary evaporator
  4. custom13.6 g of 4-cyclohexyl-benzenesulfonyl chloride separated as a reddish oil, which
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-fe06b79832ba4211b5f8354192793c54
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958910

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