참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | 2-Fluoro-5-(trifluoromethyl)phenacyl bromide | HCID 2778784 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(2-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide | HCID 21845595 | — |
반응 단계
A solution of 5.8 g of 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone in 44 ml of methanol was treated at room temperature with 2.2 g of thiourea and boiled for 1 hour. 2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05958910 |
|---|
| 출처 데이터셋 | uspto-grants-1999_09 |
|---|
| ORD ID | ord-f4535cf8a7314c42ba0ce4655d0e8876 |
|---|
| 출처 메모 | uspto-grants-1999_09 |
|---|
