참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 7-Bromoheptanoic acid | HCID 121723 | — |
| 반응물 | Thiosemicarbazide | HCID 2723789 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 21846021 | HCID 21846021 | 96% |
반응 단계
5 g of 7-bromoheptanoic acid and 2.17 g of thiosemicarbazide were introduced into 50 ml of dioxane at 90° C. and, at this temperature, 4.0 g of POCl3 were added dropwise. The mixture was then stirred at 90° C. for 1 hour. Then water was added to the mixture, and extraction 3 times with methylene chloride, drying over MgSO4 and concentration were carried out. 6.1 g (=96% yield) of product were obtained as residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05958923 |
|---|
| 출처 데이터셋 | uspto-grants-1999_09 |
|---|
| ORD ID | ord-9902cadbef08472c8438efd2e1fc0ba1 |
|---|
| 출처 메모 | uspto-grants-1999_09 |
|---|
