Ammonium Chloride → 2-(2-Bromo-4-methoxyphenyl)propan-2-ol

HRID 61913

반응식

HRID 61913 반응식
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[CH3:13][Mg+].[Br-].[Cl-].[NH4+]>C1COCC1>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([OH:12])([CH3:13])[CH3:11]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 106570061-(2-Bromo-4-methoxyphenyl)ethan-1-oneHCID 178418689HCID 178418689, 화합물

생성물 1

HCID 668348332-(2-Bromo-4-methoxyphenyl)propan-2-ol수율 69%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To the mixture of 1-(2-bromo-4-methoxyphenyl)-ethanone (300 mg) dissolved in THF solution (3 ml), MeMgBr (3 M THF solution, 0.52 ml) was added at 0° C. under nitrogen atmosphere. Then, the mixture was stirred at room temperature for 6 hrs. The reaction mixture was added with saturated aqueous solution of ammonium chloride and extracted with ethyl acetate. The organic layer was washed with saturated brine, and the residues obtained after concentration under reduced pressure were purified by silica gel column (ethyl acetate/hexane) to obtain the title compound (220 mg, 69%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. customthe residues obtained
  4. concentrationafter concentration under reduced pressure
  5. customwere purified by silica gel column (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-79c7e601161647efaa727e13ebaddad9
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440922B2

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