Methyl pivaloylacetate → HCID 178441204, 화합물

HRID 619283

반응식

HRID 619283 반응식
[CH3:1][C:2]([CH3:11])([CH3:10])[C:3](=O)[CH2:4][C:5](OC)=[O:6].C(=O)(O)O.[NH2:16][C:17]([NH2:19])=[NH:18]>C(O)C>[NH2:19][C:17]1[N:18]=[C:5]([OH:6])[CH:4]=[C:3]([C:2]([CH3:11])([CH3:10])[CH3:1])[N:16]=1

참가 물질

4

반응물 2

HCID 99597Methyl pivaloylacetateHCID 286947Carbonic acid-guanidine (1:1)

생성물 1

HCID 178441204HCID 178441204, 화합물수율 75.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 4,4-dimethyl-3-oxopentanoate (15.82 g) and guanidine carbonate (20.0 g) were mixed in 80 mL of ethanol, and the solution refluxed for 16 hours. The reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water was added. The remaining mixture was acidified to pH 5 with acetic acid, affording a white precipitate. The precipitate was collected by filtration, washed with water, and dried in a vacuum oven to give 2-amino-4-hydroxy-6-tert-butylpyrimidine (12.6 g), m.p. 285-288° C. (dec.).

후처리

  1. temperaturethe solution refluxed for 16 hours
  2. concentrationThe reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water
  3. additionwas added
  4. customaffording a white precipitate
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with water
  7. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-e49c84cbf16b4b31b5dc129dc2bbb147
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958934

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